In histopathology, feathery degeneration, formally feathery degeneration of hepatocytes, is a form of liver parenchymal cell (i.e. hepatocyte) death associated with cholestasis.[1]
Cells undergoing this form of cell death have a flocculant appearing cytoplasm,[2] and are larger than normal hepatocytes.
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Feathery degeneration is somewhat similar in appearance to ballooning degeneration, which is due to other causes (e.g. alcohol, obesity); it also has cytoplasmic clearing and cell swelling.
